Research project

Research project in cooperation between the Specialized Medical Hospital - Mansoura University and Science & Technological Development fund

Title

Diagnostic imaging for accurate diagnosisand staging of hepatic fibrosis as compared to liver biopsy.

Chronic hepatitis C affects an estimated 300 million people world wide.Egypt has a higher prevalence of HCV infection, about 12% of general population.  HCV canlead to anacuteor silent course of liver disease, progressing from liver impairment and fibrosis to cirrhosis and decompensated liver failure or hepatocellular carcinoma.

Liver biopsy is currently the golds tandard method for staging of liver fibrosis, butithas well documented complications suchas pain,bleeding and rarely death. Also,liver biopsy is expansive especial if done by guide dultra songraphy. Liver biopsy is also wide lyun accepted by many patients.

So,  there  is  a  need  for  non  invasive  methods  to  replace  liver  biopsy. Transient elastography (TE) (FibroScan; Echosens, Paris, France), is a simple, rapid, noninvasive method. It is anultrasound-based technique, used for assessment of liver tissuestiffness.

Diffusion weight edmagnetic resonance imaging (DW-MRI) isanothernon-invasive method that  allows  measurement  of  the  microscopic  motion  of  water  in  tissue  could  be  used  for diagnosis of hepatic fibrosis or cirrhosis.

Morphometric assessment of fibrosis by image analysis is becoming more sensitive and accurate methodfor assessment of hepatic fibrosis.

The aim of the project:To Evaluate Fibroscan, diffusion weighted MRI  as noninvasive tools for diagnosis of hepatic fibrosis and comparison of their performance characteristics with liver biopsy with and without morphometry in patients with chronic HCV.

The aim of the project:

To Evaluate Fibroscan, diffusion weighted MRI as noninvasive tools for diagnosis of hepatic fibrosis and comparison of their performance characteristics with liver biopsy with and without morphometry in patients with chronic HCV.

     Team Work

Prof. Shahera El-AtrebyPrinicipal Researcher
Prof. Gamal ShihaProfessor of Internal Medicine
Prof. Magdy HamedProfessor of Internal Medicine
Prof. Moneer BahgatProfessor of Internal Medicine
Prof. Seham SeifAss.Professor of Internal Medicine
Prof. Tarek El-DeyastyProfessor of Radiology
Prof. Esam Abo-BehaConsultant of Urology & Nephrology Center
Prof. Osama El-BazProfessor of Clinical Pathology
Dr. Waleed SamirPh.D. Biochemistry
Dr. Doaa HelmyLecture of Internal Medicine
Dr. Mohamed AdelLecture of Internal Medicine
Dr. Ahmed ZedAss.Lecture of Internal Medicine
Dr. Ahmed Hassan El-BanaAss.Lecture of Internal Medicine


   

Diabetic Foot Clinic

Diabetic foot is a devastating complication of diabetes for both patients and health care providers. Gangrene and amputation is usually wrongly considered as synonym for diabetic foot, although a lot of symptoms and signs usually precede such advanced pathology by several years. Strangely enough, is that of all chronic complications of diabetes, foot problems and their risk factors are the easiest to detect and the simplest to prevent. Most of the studies suggested that simple interventions can reduce amputations by up to 50-80%.

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